Two lifelong friends, who are both architects, form a business partnership. Partners is a comedy that is about a life long bromance between Joe and Louis, two architects who have been friends nearly their entire lives. They are now are business partners, owning their own small architecture firm. Joe is very rational and level headed, following his head over his heart, sometimes a detriment to his relationships. Joe is newly engaged to Ali, a beautiful jewelry designer who brings out the best in him. Louis, in contrast to Joe, is passionate, outspoken and tends to exaggerate in order to make his point. Louis' partner's name is Wyatt, and is a vegan male nurse who is soft spoken and overly understanding. As they live their lives they must find a way to adapt, redefining the bond between them both personally and professionally now that there is an addition of two other important relationships.

• David Krumholtz
• Michael Urie
• Sophia Bush
• Brandon Routh