UFC 278: Usman vs. Edwards 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 20, 2022, at Vivint Arena in Salt Lake City, Utah, United States. A UFC Welterweight Championship bout between current champion (also The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner) Kamaru Usman and Leon Edwards headlined the event. The pairing previously met at UFC on Fox: dos Anjos vs. Cowboy 2 in December 2015 where Usman defeated Edwards by unanimous decision.

• Ultimate Fighting Championship
• Leon Edwards
• Kamaru Usman
• Paulo Costa
• Luke Rockhold
• Merab Dvalishvili
• José Aldo
• Lucie Pudilová
• Yanan Wu